Antidepressants And Five Vital Facts You Need To Know

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Antidepressants And Five Vital Facts You Need To Know

I often get asked my opinion on antidepressants. Clients often ask me whether they should take them or not. I always emphasize that, off course, it is entirely up to them. Doctors can not make people take these products and equally I can not stop you. Part of being an adult is making choices for yourself. Though, I believe the more information you have on a subject, the more informed you are to make the right decision for you. Therefore, I feel it’s important to tell my clients the data pharmaceutical companies won’t.

The following are five facts that I have provided recently to clients which have given balance to their decision.

1. Antidepressants can be harmful

Many people are injured by the medical products they use. From anxiety and sleep disorders to sexual dysfunction and suicidal ideation. All antidepressant products carry a risk of side effects.

It’s possible, and even probable, for some side effects to be discounted as symptoms of the depression rather than effects of the medication. Doctors are subjected to some of the most sophisticated marketing you’ll find anywhere on the planet. And they are not necessarily pharmacological experts who understand exactly how every drug they prescribe works.

Medical drugs unquestionably do save many lives and improve the quality of many more. However, it’s important to remember that there is a huge, if not always acknowledged, financial incentive for drugs companies to develop medications that have to be taken ‘for life’. When you stop taking a drug (because you’re better, hurrah!), the manufacturer makes no more money out of you.

But make no mistake, drugs can be dangerous and side effects are not as rare as some people (are led to?) believe.

2. The premise of antidepressant usage is unproven

Drug companies currently spend around three billion pounds a year promoting the notion that depression is a purely biological illness that can be effectively treated only by (in many cases) long term usage of their products.

The first thing I tell my clients is that there is no evidence, despite the billions spent on marketing the idea, that clinical depression is caused through ‘faulty biology’ or ‘bad genes’. [1][2]

I might also add that all trials of these antidepressants are conducted by the drug companies themselves. These trials are not currently independently assessed, so they can (and do, therefore) choose not to publish studies that show only a weak or no advantage of their products over placebo. [3]

3. No antidepressant is more or less effective than any other

Despite nearly forty years of development, no single antidepressant has been shown to be any more efficacious than any other. So the newer SSRIs are not more effective or less effective than the older style Tricyclic (TCAs) or Monoamine oxidase inhibitors (MAOIs) of old. [4] The newer ones don’t work any better, although some people believe they are less toxic. However, there is evidence that switching between antidepressants to find the one that works best for the individual produces better outcomes overall. [5]

4. Dosage makes no difference to outcome

Sometimes clients tell me their doctor wants them to increase their dosage. In such cases, I generally suggest that if they feel they have to take these products, a lower dosage is always better than higher dosage.

Why? Because it’s been found that higher dosage antidepressants (taking into account the placebo effect of knowing you are on a more powerful course) make no difference to outcome.[6]

I always advise they consume these drugs at lower dosages because toxicity will be less and side effects should be weaker on the lower dosage. It’s a myth that a person will get better quicker if they are on a higher dosage of antidepressant – but it’s a dangerous myth.

5. Effective psychotherapy and/or hypnotherapy is better at preventing relapse than drugs

You might also tell your client that effective psychotherapy and/or hypnotherapy also changes the way the brain works, but in a good way and without side effects. And research has found that, because it teaches skills that can be used for life, it is much better at preventing relapse into depression than antidepressants. [7]

You could also mention that a common withdrawal symptom of coming off antidepressants is feeling low. This is because the brain is trying to adjust to life without the drug. This withdrawal symptom is often not recognized for what it is, and is instead interpreted as an indication that the person needs to go back to taking the drug, because they are still ‘depressed underneath’.

Remember that!

So it’s worth waiting for the withdrawal symptoms to subside before any decision is made regarding further consumption of these drugs.


I would like to emphasise that I am not in the business of telling others that they must or mustn’t take these drugs. I also say that if they do take them, I will still gladly help them therapeutically.

Some therapists might consider it none of their business to comment on whether their clients do or don’t take psychotropic drugs. However, I am often asked my opinion as a therapist with my nursing history. Due to my medical background it is within my nature to research such questions, hence the references at the bottom. But considering the numbers of patients who are injured or at risk of being injured [8] taking these products, I believe I have a duty of care to at least provide a counterbalanced view if asked.

People do get better without these drugs.


(1) See: Antonuccio, David O.; Danton, William G.; DeNelsky, Garland Y. “Psychotherapy versus medication for depression: Challenging the conventional wisdom with data.” Professional Psychology: Research and Practice, Vol 26(6), Dec 1995, 574-585. A meta-analysis of over 100,000 pieces of research into the causes, consequences, and best treatments for clinical depression, conducted from 1978-1993.

(2) At least 90 studies have been done to discover what happens when monoamine levels are reduced in people. A meta-analysis of this research was conducted at the University of Amsterdam. It found that there is no evidence that lowered serotonin acts as a depressant. Ruhé HG, Mason NS, Schene AH. Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Molecular Psychiatry. 2007 Apr;12(4):331-59.

(3) Irving Kirsch, PhD. The Emperors New Drugs: Exploding the Antidepressant Myth. Bodley Head (2009).

(4) See: Kirsch, I., & Moncrieff, J. (July 2007). “Clinical trials and the response rate illusion”. Contemporary Clinical Trials 28 (4): 348-51.doi:10.1016/j.cct.2006.10.012. PMID17182286. And also see: Kirsch, Irving; Sapirstein, Guy. Listening to Prozac but Hearing Placebo: A Meta-Analysis of Antidepressant Medication. Prevention & Treatment, Vol 1(2), Jun 1998.

(5) See: Equal on average does not mean equal for everyone. And see also the referenced article: K Kroenke et al. Similar effectiveness of paroxetine, fluoxetine and sertraline in primary care. JAMA 2001 286: 2947-2995.

(6) Antonuccio, David O.; Danton, William G.; DeNelsky, Garland Y. “Psychotherapy versus medication for depression: Challenging the conventional wisdom with data.”

(7) Nierenberg AA, Petersen TJ, Alpert JE. Prevention of relapse and recurrence in depression: the role of long-term pharmacotherapy and psychotherapy. Journal of Clinical Psychiatry. 2003;64 Suppl 15:13-7.

(8) For example, Antidepressants are linked to thicker arteries.
Emory University. “Antidepressants linked to thicker arteries.” ScienceDaily. ScienceDaily, 2 April 2011. <>.

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